Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00557115" target="_blank" >RIV/61388963:_____/22:00557115 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s13311-022-01228-5" target="_blank" >https://doi.org/10.1007/s13311-022-01228-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13311-022-01228-5" target="_blank" >10.1007/s13311-022-01228-5</a>
Alternative languages
Result language
angličtina
Original language name
Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
Original language description
One of the greatest challenges with successful pharmaceutical treatments of central nervous system (CNS) diseases is the delivery of drugs into their target sites with appropriate concentrations. For example, the physically tight blood-brain barrier (BBB) effectively blocks compounds from penetrating into the brain, also by the action of metabolizing enzymes and efflux transport mechanisms. However, many endogenous compounds, including both smaller compounds and macromolecules, like amino acids, sugars, vitamins, nucleosides, hormones, steroids, and electrolytes, have their peculiar internalization routes across the BBB. These delivery mechanisms, namely carrier-mediated transport and receptor-mediated transcytosis have been utilized to some extent in brain-targeted drug development. The incomplete knowledge of the BBB and the smaller than a desirable number of chemical tools have hindered the development of successful brain-targeted pharmaceutics. This review discusses the recent advancements achieved in the field from the point of medicinal chemistry view and discusses how brain drug delivery can be improved in the future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurotherapeutics
ISSN
1933-7213
e-ISSN
1878-7479
Volume of the periodical
19
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
35
Pages from-to
942-976
UT code for WoS article
000779225400001
EID of the result in the Scopus database
2-s2.0-85128867471