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Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00557947" target="_blank" >RIV/61388963:_____/22:00557947 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.2174/1874467214666210906125959" target="_blank" >https://doi.org/10.2174/1874467214666210906125959</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1874467214666210906125959" target="_blank" >10.2174/1874467214666210906125959</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics

  • Original language description

    The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dys-functions. Recently, the first few vaccines were approved by World Health Organization (WHO) and can eventually save millions of lives. Even though, few drugs are used in emergency like Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism are potential therapeutic targets. This perspective review provides the molecular overview of SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology, and pathogenesis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10607 - Virology

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Molecular Pharmacology

  • ISSN

    1874-4672

  • e-ISSN

    1874-4702

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    16

  • Pages from-to

    418-433

  • UT code for WoS article

    000819380800009

  • EID of the result in the Scopus database

    2-s2.0-85130861775