Possible involvement of apoptosis in the antipsychotics side effects: A mini-review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00558473" target="_blank" >RIV/61388963:_____/22:00558473 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1111/1440-1681.13671" target="_blank" >https://doi.org/10.1111/1440-1681.13671</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.13671" target="_blank" >10.1111/1440-1681.13671</a>
Alternative languages
Result language
angličtina
Original language name
Possible involvement of apoptosis in the antipsychotics side effects: A mini-review
Original language description
Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally, they are divided into typical and atypical ones, according to the fact that atypical antipsychotics induce fewer side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signalling pathways. Antipsychotics produce undesirable side effects that range from relatively minor to life threatening. In vitro and in vivo studies have pointed to neurotoxic effect exerted by some antipsychotics and have shown that apoptosis might play role in some side effects induced by antipsychotics, including tardive dyskinesia, weight gain, agranulocytosis, osteoporosis, myocarditis, etc. Although cumulative data have suggested safety of atypical antipsychotics use during pregnancy, some of them have been shown to induce apoptotic neurodegenerative and structural changes in fetal brains with long-lasting impact on cognitive impairment of offspring. Typical antipsychotics seem to be more cytotoxic than atypical ones. Recently, epidemiological studies have shown lower incidence of cancer in schizophrenic patients that suggest the ability of antipsychotics to suppress risk of cancer development. Some antipsychotics have been reported to inhibit cancer cell proliferation and induce their apoptosis. Therefore, antipsychotics apoptotic effect may be used as a tool in the treatment of some types of cancer, especially in combinatorial therapies. In this mini-review, we focused on pro- and antiapoptotic or 'Dr. Jekyll and Mr. Hyde' effects of antipsychotics, which can be involved in their side effects, as well as their promising therapeutic indications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Pharmacology and Physiology
ISSN
0305-1870
e-ISSN
1440-1681
Volume of the periodical
49
Issue of the periodical within the volume
8
Country of publishing house
AU - AUSTRALIA
Number of pages
12
Pages from-to
836-847
UT code for WoS article
000807860200001
EID of the result in the Scopus database
2-s2.0-85131375412