Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00558473" target="_blank" >RIV/61388963:_____/22:00558473 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1111/1440-1681.13671" target="_blank" >https://doi.org/10.1111/1440-1681.13671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1440-1681.13671" target="_blank" >10.1111/1440-1681.13671</a>

Result language

angličtina

Original language name

Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

Original language description

Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally, they are divided into typical and atypical ones, according to the fact that atypical antipsychotics induce fewer side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signalling pathways. Antipsychotics produce undesirable side effects that range from relatively minor to life threatening. In vitro and in vivo studies have pointed to neurotoxic effect exerted by some antipsychotics and have shown that apoptosis might play role in some side effects induced by antipsychotics, including tardive dyskinesia, weight gain, agranulocytosis, osteoporosis, myocarditis, etc. Although cumulative data have suggested safety of atypical antipsychotics use during pregnancy, some of them have been shown to induce apoptotic neurodegenerative and structural changes in fetal brains with long-lasting impact on cognitive impairment of offspring. Typical antipsychotics seem to be more cytotoxic than atypical ones. Recently, epidemiological studies have shown lower incidence of cancer in schizophrenic patients that suggest the ability of antipsychotics to suppress risk of cancer development. Some antipsychotics have been reported to inhibit cancer cell proliferation and induce their apoptosis. Therefore, antipsychotics apoptotic effect may be used as a tool in the treatment of some types of cancer, especially in combinatorial therapies. In this mini-review, we focused on pro- and antiapoptotic or 'Dr. Jekyll and Mr. Hyde' effects of antipsychotics, which can be involved in their side effects, as well as their promising therapeutic indications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Experimental Pharmacology and Physiology

ISSN

0305-1870

e-ISSN

1440-1681

Volume of the periodical

49

Issue of the periodical within the volume

8

Country of publishing house

AU - AUSTRALIA

Number of pages

12

Pages from-to

836-847

UT code for WoS article

000807860200001

EID of the result in the Scopus database

2-s2.0-85131375412