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Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00558473" target="_blank" >RIV/61388963:_____/22:00558473 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1111/1440-1681.13671" target="_blank" >https://doi.org/10.1111/1440-1681.13671</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/1440-1681.13671" target="_blank" >10.1111/1440-1681.13671</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

  • Original language description

    Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally, they are divided into typical and atypical ones, according to the fact that atypical antipsychotics induce fewer side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signalling pathways. Antipsychotics produce undesirable side effects that range from relatively minor to life threatening. In vitro and in vivo studies have pointed to neurotoxic effect exerted by some antipsychotics and have shown that apoptosis might play role in some side effects induced by antipsychotics, including tardive dyskinesia, weight gain, agranulocytosis, osteoporosis, myocarditis, etc. Although cumulative data have suggested safety of atypical antipsychotics use during pregnancy, some of them have been shown to induce apoptotic neurodegenerative and structural changes in fetal brains with long-lasting impact on cognitive impairment of offspring. Typical antipsychotics seem to be more cytotoxic than atypical ones. Recently, epidemiological studies have shown lower incidence of cancer in schizophrenic patients that suggest the ability of antipsychotics to suppress risk of cancer development. Some antipsychotics have been reported to inhibit cancer cell proliferation and induce their apoptosis. Therefore, antipsychotics apoptotic effect may be used as a tool in the treatment of some types of cancer, especially in combinatorial therapies. In this mini-review, we focused on pro- and antiapoptotic or 'Dr. Jekyll and Mr. Hyde' effects of antipsychotics, which can be involved in their side effects, as well as their promising therapeutic indications.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Pharmacology and Physiology

  • ISSN

    0305-1870

  • e-ISSN

    1440-1681

  • Volume of the periodical

    49

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    AU - AUSTRALIA

  • Number of pages

    12

  • Pages from-to

    836-847

  • UT code for WoS article

    000807860200001

  • EID of the result in the Scopus database

    2-s2.0-85131375412