Unified Total Synthesis of Diverse Meroterpenoids from Ganoderma Applanatum

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00559131" target="_blank" >RIV/61388963:_____/22:00559131 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10457021
Result on the web
<a href="https://doi.org/10.1021/acs.orglett.2c01633" target="_blank" >https://doi.org/10.1021/acs.orglett.2c01633</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.2c01633" target="_blank" >10.1021/acs.orglett.2c01633</a>

Result language
angličtina
Original language name
Unified Total Synthesis of Diverse Meroterpenoids from Ganoderma Applanatum
Original language description
A unified approach to meroterpenoids applanatumols B, V, W, X, and Y produced by the medicinal fungus Ganoderma applanatum and 2′-epi-spiroapplanatumine O is presented. The key synthetic sequence consists of a tandem anionic ketone allylation/oxy-Cope rearrangement/α-oxygenation furnishing an α-aminoxy ketone and a persistent radical effect-based 5-exo-trig cyclization leading to the trisubstituted cyclopentane core. The relative configuration of applanatumol V has to be revised. Some compounds display significant cytotoxic and antioxidant properties.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA16-18513S" target="_blank" >GA16-18513S: Tandem Sigmatropic Rearrangement/Radical Reactions - A New Productive Alliance in Organic Chemistry</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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