Multiresponsive fluorinated polymers as a theranostic platform using 19F MRI

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00559242" target="_blank" >RIV/61388963:_____/22:00559242 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/22:00559152 RIV/00064165:_____/22:10445445 RIV/00216208:11110/22:10445445 RIV/00216208:11310/22:10445445
Result on the web
<a href="https://doi.org/10.1016/j.eurpolymj.2022.111381" target="_blank" >https://doi.org/10.1016/j.eurpolymj.2022.111381</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2022.111381" target="_blank" >10.1016/j.eurpolymj.2022.111381</a>

Result language
angličtina
Original language name
Multiresponsive fluorinated polymers as a theranostic platform using 19F MRI
Original language description
Drug delivery systems (DDSs) can significantly improve the biodistribution and pharmacokinetics of various drugs. Herein, we describe diblock polymers of poly(2-methyloxazoline) and N-(2,2′-difluoroethyl)acrylamide with N-[2-(ferrocenylcarboxamido)ethyl]acrylamide that can be used as advanced DDSs. These thermoresponsive diblock copolymers self-assemble when heated to body temperature but disassemble when exposed to oxidative conditions (reactive oxygen species, ROS), releasing their cargo. Moreover, our polymers are not prone to spontaneous oxidation by air or hydrogen peroxide under physiological conditions but are highly sensitive to ROS under acidic conditions. Advantageously, the biodistribution of our DDS can be monitored with fluorine-19 magnetic resonance imaging (19F MRI). Therefore, our polymers could be used in both local and systemic drug delivery systems in ROS-rich environments, such as tumors or inflamed tissues. Additionally, the properties of our polymers could be widely modified to meet the demands of various clinical applications. Overall, we demonstrate that our copolymers (i) release their cargo preferentially in an ROS-rich environment, (ii) are biocompatible, and (iii) can be easily visualized in vivo.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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