One-pot synthesis of 4-substituted 2-fluoroalkyloxazoles from NH-1,2,3-triazoles and fluoroalkylated acid anhydrides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00559497" target="_blank" >RIV/61388963:_____/22:00559497 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1039/D2NJ02461F" target="_blank" >https://doi.org/10.1039/D2NJ02461F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2nj02461f" target="_blank" >10.1039/d2nj02461f</a>

Result language
angličtina
Original language name
One-pot synthesis of 4-substituted 2-fluoroalkyloxazoles from NH-1,2,3-triazoles and fluoroalkylated acid anhydrides
Original language description
An efficient one-pot method for the synthesis of 2-fluoroalkyloxazoles from 4-substituted NH-1,2,3-triazoles, fluorinated anhydrides and triethylamine was developed. Structurally diverse fluoroalkylated oxazoles (RF = CF3, C2F5, CF2Cl, CF2H) were prepared in high yields from readily available starting reagents in mild conditions. An alternative direct method for fluoroalkylated oxazole synthesis from electron-rich NH-triazoles using acetonitrile as the solvent was described.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/LTAUSA18037" target="_blank" >LTAUSA18037: Synthesis and reactivity of N-fluoroalkylated compounds</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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