Formation of ibrutinib solvates: so similar, yet so different

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00571611" target="_blank" >RIV/61388963:_____/23:00571611 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/23:00571611 RIV/60461373:22340/23:43927948 RIV/60461373:22810/23:43927948
Result on the web
<a href="https://hdl.handle.net/11104/0342697" target="_blank" >https://hdl.handle.net/11104/0342697</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1107/S2052252523001197" target="_blank" >10.1107/S2052252523001197</a>

Result language
angličtina
Original language name
Formation of ibrutinib solvates: so similar, yet so different
Original language description
The transformation processes of non-solvated ibrutinib into a series of halogenated benzene solvates are explored in detail here. The transformation was studied in real time by X-ray powder diffraction in a glass capillary. Crystal structures of chlorobenzene, bromobenzene and iodobenzene solvates are isostructural, whereas the structure of fluorobenzene solvate is different. Four different mechanisms for transformation were discovered despite the similarity in the chemical nature of the solvents and crystal structures of the solvates formed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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