Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00572583" target="_blank" >RIV/61388963:_____/23:00572583 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/23:94756 RIV/60460709:41340/23:94756

Result on the web

<a href="https://doi.org/10.1007/s11101-023-09869-w" target="_blank" >https://doi.org/10.1007/s11101-023-09869-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-023-09869-w" target="_blank" >10.1007/s11101-023-09869-w</a>

Result language

angličtina

Original language name

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Original language description

Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from G. kola, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of G. kola. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in G. kola may be used as a lead in the drug development.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10611 - Plant sciences, botany

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

1572-980X

Volume of the periodical

22

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

47

Pages from-to

1305-1351

UT code for WoS article

000993359900002

EID of the result in the Scopus database

2-s2.0-85160255192