Hydrogen-Bonding Interactions of 8-Substituted Purine Derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00573771" target="_blank" >RIV/61388963:_____/23:00573771 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10466999
Result on the web
<a href="https://doi.org/10.1021/acsomega.3c03244" target="_blank" >https://doi.org/10.1021/acsomega.3c03244</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsomega.3c03244" target="_blank" >10.1021/acsomega.3c03244</a>

Result language
angličtina
Original language name
Hydrogen-Bonding Interactions of 8-Substituted Purine Derivatives
Original language description
Hydrogen bonding between nucleobases is a crucial noncovalent interaction for life on Earth. Canonical nucleobases form base pairs according to two main geometries: Watson–Crick pairing, which enables the static functions of nucleic acids, such as the storing of genetic information, and Hoogsteen pairing, which facilitates the dynamic functions of these biomacromolecules. This precisely tuned system can be affected by oxidation or substitution of nucleobases, leading to changes in their hydrogen-bonding patterns. This paper presents an investigation into the intermolecular interactions of various 8-substituted purine derivatives with their hydrogen-bonding partners. The systems were analyzed using nuclear magnetic resonance spectroscopy and density functional theory calculations. Our results demonstrate that the stability of hydrogen-bonded complexes, or base pairs, depends primarily on the number of intermolecular H-bonds and their donor–acceptor alternation. No strong preferences for a particular geometry, either Watson–Crick or Hoogsteen, were found.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

Project
<a href="/en/project/GA22-15374S" target="_blank" >GA22-15374S: Proton transfer reactions studied by NMR spectroscopy and advanced quantum-chemical calculations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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