Modified activities of macrophages’ deubiquitinating enzymes after Francisella infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00577416" target="_blank" >RIV/61388963:_____/23:00577416 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/24:00560449 RIV/60461373:22340/23:43928725
Result on the web
<a href="https://doi.org/10.3389/fimmu.2023.1252827" target="_blank" >https://doi.org/10.3389/fimmu.2023.1252827</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2023.1252827" target="_blank" >10.3389/fimmu.2023.1252827</a>
Alternative languages
Result language
angličtina
Original language name
Modified activities of macrophages’ deubiquitinating enzymes after Francisella infection
Original language description
Francisella tularensis influences several host molecular/signaling pathways during infection. Ubiquitination and deubiquitination are among the most important regulatory mechanisms and respectively occur through attachment or removal of the ubiquitin molecule. The process is necessary not only to mark molecules for degradation, but also, for example, to the activation of signaling pathways leading to pro-inflammatory host response. Many intracellular pathogens, including Francisella tularensis, have evolved mechanisms of modifying such host immune responses to escape degradation. Here, we describe that F. tularensis interferes with the host's ubiquitination system. We show increased total activity of deubiquitinating enzymes (DUBs) in human macrophages after infection, while confirm reduced enzymatic activities of two specific DUBs (USP10 and UCH-L5), and demonstrate increased activity of USP25. We further reveal the enrichment of these three enzymes in exosomes derived from F. tularensis-infected cells. The obtained results show the regulatory effect on ubiquitination mechanism in macrophages during F. tularensis infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
1664-3224
Volume of the periodical
14
Issue of the periodical within the volume
September
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1252827
UT code for WoS article
001085763100001
EID of the result in the Scopus database
2-s2.0-85174231264