Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00578949" target="_blank" >RIV/61388963:_____/23:00578949 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00578949
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/75" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/75</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Design and synthesis of new molecular tools to probe cytosolic proteins in bacteria resistant to rifamycin antibiotics
Original language description
Rifamycin-derived antibiotics are highly efficient inhibitors of prokaryotic DNA-dependent RNA polymerase (RNAP) used in treatment of many bacterial infections, including tuberculosis. During exposure, however, bacteria develop resistance to antibiotics, and several modifications of rifamycin skeleton that inhibit RNAP binding have already been discovered. A photo-crosslinking probe 1(Fig. 1) with biotin handle based on rifamycin B was recently used for identifying specific protein that displaces antibiotic from RNAP in Streptomyces venezulae.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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