Solid-phase synthesis as a tool to create exactly defined, branched polymer vectors for cell membrane targeting
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00582834" target="_blank" >RIV/61388963:_____/24:00582834 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/24:00582834 RIV/00216208:11110/24:10478577
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.macromol.3c02600" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.macromol.3c02600</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.3c02600" target="_blank" >10.1021/acs.macromol.3c02600</a>
Alternative languages
Result language
angličtina
Original language name
Solid-phase synthesis as a tool to create exactly defined, branched polymer vectors for cell membrane targeting
Original language description
Modern drug formulations often require, besides the active drug molecule, auxiliaries to enhance their pharmacological properties. Tailor-made, biocompatible polymers covalently connected to the drug molecule can fulfill this function by increasing its solubility, reducing its toxicity, and guiding it to a specific target. If targeting membrane-bound proteins, localization of the drug close to the cell membrane and its target is beneficial to increase drug efficiency and residence time. In this study, we present the synthesis of highly defined, branched polymeric structures with membrane-binding properties. One to three hydrophilic poly(ethylene oxide) or poly(2-ethyloxazoline) side chains were connected via a peptoid backbone using a two-step iterative protocol for solid-phase peptoid synthesis. Additional groups, e.g., a hydrophobic anchor for membrane attachment, were introduced. Due to the nature of solid-phase synthesis, the number and order of the side chains and additional units can be precisely defined. The method proved to be versatile for the generation of multifunctional, branched polymeric structures of molecular weights up to approximately 7000 g mol–1. The behavior of all compounds towards biological membranes and cells was investigated using liposomes as cell membrane models, HEK293 and U251-MG cell lines, and red blood cells, thereby demonstrating their potential value as drug auxiliaries with cell membrane affinity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecules
ISSN
0024-9297
e-ISSN
1520-5835
Volume of the periodical
57
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
22
Pages from-to
1050-1071
UT code for WoS article
001162248000001
EID of the result in the Scopus database
2-s2.0-85184746879