Organization of Carotenoid Aggregates in Membranes Studied Selectively using Resonance Raman Optical Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00583160" target="_blank" >RIV/61388963:_____/24:00583160 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/smll.202306707" target="_blank" >https://doi.org/10.1002/smll.202306707</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/smll.202306707" target="_blank" >10.1002/smll.202306707</a>
Alternative languages
Result language
angličtina
Original language name
Organization of Carotenoid Aggregates in Membranes Studied Selectively using Resonance Raman Optical Activity
Original language description
In living organisms, carotenoids are incorporated in biomembranes, remarkably modulating their mechanical characteristics, fluidity, and permeability. Significant resonance enhancement of Raman optical activity (ROA) signals of carotenoid chiral aggregates makes resonance ROA (RROA), a highly selective tool to study exclusively carotenoid assemblies in model membranes. Hence, RROA is combined with electronic circular dichroism (ECD), dynamic light scattering (DLS), molecular dynamics, and quantum-chemical calculations to shed new light on the carotenoid aggregation in dipalmitoylphosphatidylcholine (DPPC) liposomes. Using representative members of the carotenoid family: apolar alpha-carotene and more polar fucoxanthin and zeaxanthin, the authors demonstrate that the stability of carotenoid aggregates is directly linked with their orientation in membranes and the monomer structures inside the assemblies. In particular, polyene chain distortion of alpha-carotene molecules is an important feature of J-aggregates that show increased orientational freedom and stability inside liposomes compared to H-assemblies of more polar xanthophylls. In light of these results, RROA emerges as a new tool to study active compounds and drugs embedded in membranes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Small
ISSN
1613-6810
e-ISSN
1613-6829
Volume of the periodical
20
Issue of the periodical within the volume
26
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2306707
UT code for WoS article
001146023300001
EID of the result in the Scopus database
2-s2.0-85182712588