An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00583336" target="_blank" >RIV/61388963:_____/24:00583336 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10482235
Result on the web
<a href="https://doi.org/10.1038/s44319-023-00016-2" target="_blank" >https://doi.org/10.1038/s44319-023-00016-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s44319-023-00016-2" target="_blank" >10.1038/s44319-023-00016-2</a>
Alternative languages
Result language
angličtina
Original language name
An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis
Original language description
Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced obesity (DIO) by high fat diets (HFD) exerts adverse influence on hAN. However, the effects of anti-obesity compounds on hAN are not known. To address this, we administered a lipidized analogue of an anti-obesity neuropeptide, Prolactin Releasing Peptide (PrRP), so-called LiPR, to mice. In the HFD context, LiPR rescued the survival of adult-born hypothalamic neurons and increased the number of aNSCs by reducing their activation. LiPR also rescued the reduction of immature hippocampal neurons and modulated calcium dynamics in iPSC-derived human neurons. In addition, some of these neurogenic effects were exerted by another anti-obesity compound, Liraglutide. These results show for the first time that anti-obesity neuropeptides influence adult neurogenesis and suggest that the neurogenic process can serve as a target of anti-obesity pharmacotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Reports
ISSN
1469-221X
e-ISSN
1469-3178
Volume of the periodical
25
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
27
Pages from-to
351-377
UT code for WoS article
001204737100020
EID of the result in the Scopus database
2-s2.0-85183333411