Combinatorial libraries of bipodal binders of the insulin receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00584024" target="_blank" >RIV/61388963:_____/24:00584024 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/cmdc.202400145" target="_blank" >https://doi.org/10.1002/cmdc.202400145</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.202400145" target="_blank" >10.1002/cmdc.202400145</a>

Result language
angličtina
Original language name
Combinatorial libraries of bipodal binders of the insulin receptor
Original language description
We adopeted a strategy focused on synthesizing extensive combinatorial libraries of bipodal compounds consisting of two distinct peptides linked to a molecular scaffold. These constructs, evaluated in a resin bead-bound format, were designed to assess their binding to the insulin receptor. Despite notable nonspecific binding, our approach successfully generated and tested millions of compounds. Rigorous evaluations via flow cytometry and specific antibodies revealed peptide sequences with specific interactions at either receptor binding Site 1 or 2.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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