Unveiling the DHX15–G-patch interplay in retroviral RNA packaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00599200" target="_blank" >RIV/61388963:_____/24:00599200 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/24:00599200 RIV/60461373:22310/24:43930251 RIV/60461373:22330/24:43930251 RIV/60461373:22810/24:43930251
Result on the web
<a href="https://doi.org/10.1073/pnas.2407990121" target="_blank" >https://doi.org/10.1073/pnas.2407990121</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2407990121" target="_blank" >10.1073/pnas.2407990121</a>
Alternative languages
Result language
angličtina
Original language name
Unveiling the DHX15–G-patch interplay in retroviral RNA packaging
Original language description
We explored how a simple retrovirus, Mason-Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase, typically engaged in RNA processing. Through advanced genetic engineering techniques, we showed that M-PMV recruits DHX15 by mimicking cellular mechanisms, relocating it from the nucleus to the cytoplasm to aid in viral assembly. This interaction is essential for the correct packaging of the viral genome and critical for its infectivity. Our findings offer unique insights into the mechanisms of viral manipulation of host cellular processes, highlighting a sophisticated strategy that viruses employ to leverage cellular machinery for their replication. This study adds valuable knowledge to the understanding of viral-host interactions but also suggests a common evolutionary history between cellular processes and viral mechanisms. This finding opens a unique perspective on the export mechanism of intron-retaining mRNAs in the packaging of viral genetic information and potentially develop ways to stop it.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
1091-6490
Volume of the periodical
121
Issue of the periodical within the volume
40
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
e2407990121
UT code for WoS article
001348579900005
EID of the result in the Scopus database
2-s2.0-85204941381