Computational strategies for the design of proteolysis targeting chimera degraders: Artificial intelligence enabled PROTAC design

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00601208" target="_blank" >RIV/61388963:_____/24:00601208 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/bs.armc.2024.10.002" target="_blank" >https://doi.org/10.1016/bs.armc.2024.10.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.armc.2024.10.002" target="_blank" >10.1016/bs.armc.2024.10.002</a>

Result language
angličtina
Original language name
Computational strategies for the design of proteolysis targeting chimera degraders: Artificial intelligence enabled PROTAC design
Original language description
Proteolysis targeting chimera (PROTAC) is a tool that can achieve chemical knockdown of proteins via the ubiquitin-proteasome pathway, which is a new strategy for drug discovery and development. PROTACs can induce selective degradation of target proteins by binding and not necessarily inhibiting them and thus have the potential to access the undruggable proteome. Academic and industrial pipelines employ computational models and tools that utilize existing experimental data from previous efforts to identify and rationally design new degraders. This chapter describes the computational-enabled methods for PROTAC degrader design and ternary complex prediction and highlights the importance of online tools in the advancement of the targeted protein degradation field.
Czech name
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Czech description
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Project
<a href="/en/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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