Breaking the cellular defense: the role of autophagy evasion in Francisella virulence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00603971" target="_blank" >RIV/61388963:_____/24:00603971 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/25:00564133
Result on the web
<a href="https://doi.org/10.3389/fcimb.2024.1523597" target="_blank" >https://doi.org/10.3389/fcimb.2024.1523597</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2024.1523597" target="_blank" >10.3389/fcimb.2024.1523597</a>
Alternative languages
Result language
angličtina
Original language name
Breaking the cellular defense: the role of autophagy evasion in Francisella virulence
Original language description
Many pathogens have evolved sophisticated strategies to evade autophagy, a crucial cellular defense mechanism that typically targets and degrades invading microorganisms. By subverting or inhibiting autophagy, these pathogens can create a more favorable environment for their replication and survival within the host. For instance, some bacteria secrete factors that block autophagosome formation, while others might escape from autophagosomes before degradation. These evasion tactics are critical for the pathogens' ability to establish and maintain infections. Understanding the mechanisms by which pathogens avoid autophagy is crucial for developing new therapeutic strategies, as enhancing autophagy could bolster the host's immune response and aid in the elimination of pathogenic bacteria. Francisella tularensis can manipulate host cell pathways to prevent its detection and destruction by autophagy, thereby enhancing its virulence. Given the potential for F. tularensis to be used as a bioterrorism agent due to its high infectivity and ability to cause severe disease, research into how this pathogen evades autophagy is of critical importance. By unraveling these mechanisms, new therapeutic approaches could be developed to enhance autophagic responses and strengthen host defense against this and other similarly evasive pathogens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular and Infection Microbiology
ISSN
2235-2988
e-ISSN
2235-2988
Volume of the periodical
14
Issue of the periodical within the volume
December
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1523597
UT code for WoS article
001390181900001
EID of the result in the Scopus database
2-s2.0-85214139736