Physical stabilization of water-soluble PVA nanofibrous materials functionalized with biologically active substances

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00604306" target="_blank" >RIV/61388963:_____/24:00604306 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24210/24:00012840 RIV/46747885:24510/24:00012840
Result on the web
<a href="https://doi.org/10.37904/nanocon.2023.4793" target="_blank" >https://doi.org/10.37904/nanocon.2023.4793</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2023.4793" target="_blank" >10.37904/nanocon.2023.4793</a>

Result language
angličtina
Original language name
Physical stabilization of water-soluble PVA nanofibrous materials functionalized with biologically active substances
Original language description
Tissue engineering aims to develop materials that enhance biological activity and promote tissue healing and regeneration. One promising approach is to functionalize nanofibrous materials with antimicrobial substances, such as lipophosphonoxin (LPPO), and use water-soluble polymers like polyvinyl alcohol (PVA) to incorporate bioactive molecules into fibers. However, water-soluble materials often face the issue of burst release, releasing over 90% of the active substances within the initial 24 hours. This research focuses on preparing functionalized nanofibrous materials based on PVA containing the experimental antimicrobial compound LPPO and subsequent physical stabilization of the materials using the Heat treatment method. The applied stabilization successfully reduced the incorporated substance's release rate by up to 50%. The resulting materials have the potential to provide functional cross-linked PVA nanofiber scaffolds for regenerative medicine applications in large and chronic skin injuries.
Czech name
—
Czech description
—

Project
<a href="/en/project/EH22_008%2F0004562" target="_blank" >EH22_008/0004562: Excellent Research in Regenerative Medicine</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
NANOCON 2023. Proceedings 15th International Conference on Nanomaterials - Research & Application
ISBN
978-80-88365-15-0
ISSN
2694-930X
e-ISSN
—
Number of pages
8
Pages from-to
319-326
Publisher name
TANGER
Place of publication
Ostrava
Event location
Brno
Event date
Oct 18, 2023
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
001234125400051

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