Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00616773" target="_blank" >RIV/61388963:_____/25:00616773 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/25:00380791 RIV/00064165:_____/25:10492426

Result on the web

<a href="https://doi.org/10.1186/s40364-025-00725-x" target="_blank" >https://doi.org/10.1186/s40364-025-00725-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40364-025-00725-x" target="_blank" >10.1186/s40364-025-00725-x</a>

Result language

angličtina

Original language name

Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms

Original language description

Background: Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source of genome instability leading to oncogenesis, whereas small PIWI-interacting RNAs (piRNAs) act as cellular suppressors of TEs. However, the roles of TEs and piRNAs in MDS remain unclear. Methods: In this study, we examined TE and piRNA expression through parallel RNA and small RNA sequencing of CD34+ hematopoietic stem cells from MDS patients. Results: Comparative analysis of TE and piRNA expression between MDS and control samples revealed several significantly dysregulated molecules. However, significant differences were observed between lower-risk MDS (LR-MDS) and higher-risk MDS (HR-MDS) samples. In HR-MDS, we found an inverse correlation between decreased TE levels and increased piRNA expression and these TE and piRNA levels were significantly associated with patient outcomes. Importantly, the upregulation of PIWIL2, which encodes a key factor in the piRNA pathway, independently predicted poor prognosis in MDS patients, underscoring its potential as a valuable disease marker. Furthermore, pathway analysis of RNA sequencing data revealed that dysregulation of the TE-piRNA axis is linked to the suppression of processes related to energy metabolism, the cell cycle, and the immune response, suggesting that these disruptions significantly affect cellular activity. Conclusions: Our findings demonstrate the parallel dysregulation of TEs and piRNAs in HR-MDS patients, highlighting their potential role in MDS progression and indicating that the PIWIL2 level is a promising molecular marker for prognosis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/NU20-03-00412" target="_blank" >NU20-03-00412: Role of transposable elements and PIWI-interacting RNAs in myelodysplastic syndrome and their potential clinical applications</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOMARK RES

ISSN

2050-7771

e-ISSN

2050-7771

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

13

UT code for WoS article

001405663200001

EID of the result in the Scopus database

2-s2.0-85218199860