Lipid demixing reduces energy barriers for high-curvature vesicle budding
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00617215" target="_blank" >RIV/61388963:_____/25:00617215 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.bpj.2024.12.012" target="_blank" >https://doi.org/10.1016/j.bpj.2024.12.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bpj.2024.12.012" target="_blank" >10.1016/j.bpj.2024.12.012</a>
Alternative languages
Result language
angličtina
Original language name
Lipid demixing reduces energy barriers for high-curvature vesicle budding
Original language description
Under standard physiological conditions, budding relies on asymmetries, including differences in leaflet composition, area, and osmotic conditions, and involves large curvature changes in nanoscale lipid vesicles. So far, the combined impact of asymmetry and high curvatures on budding has remained unknown. Here, using the continuum elastic theory, the budding pathway is detailed under realistic conditions. The model enables a quantitative description of the budding process and the budded state of both ideally and nonideally mixed lipid nanoscale vesicles. It shows that budding is less favored in smaller vesicles but that lipid demixing can significantly reduce its energy barrier, and yet high compositional deviations of more than 7% between the bud and vesicle only occur with phase separation on the bud.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biophysical Journal
ISSN
0006-3495
e-ISSN
1542-0086
Volume of the periodical
124
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1741-1746
UT code for WoS article
001505555200002
EID of the result in the Scopus database
2-s2.0-85212932951