Structural plasticity of the FOXO-DBD:p53-TAD interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00635728" target="_blank" >RIV/61388963:_____/25:00635728 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00635728 RIV/00216208:11310/25:10498607
Result on the web
<a href="https://doi.org/10.1038/s41467-025-59106-5" target="_blank" >https://doi.org/10.1038/s41467-025-59106-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-025-59106-5" target="_blank" >10.1038/s41467-025-59106-5</a>
Alternative languages
Result language
angličtina
Original language name
Structural plasticity of the FOXO-DBD:p53-TAD interaction
Original language description
The transcription factors FOXO4 and p53 regulate aging, and their deregulation has been linked to several diseases, including cancer. Under stress conditions, cellular senescence is promoted by p53 sequestration and senescence-associated protein p21 transcriptional upregulation induced by interactions between the FOXO4 Forkhead DNA-binding domain and the p53 transactivation domain. However, the molecular details of these interactions remain unclear. Here, we report that these interactions between p53 and FOXO4 domains are highly heterogeneous. The p53 transactivation domain primarily interacts with the region formed by the N-terminal helical bundle of the FOXO4 Forkhead domain but retains a substantial degree of flexibility in the complex. In addition, NMR data-driven molecular simulations suggest that p53 interacts with FOXO4 through multiple binding modes. Overall, our findings not only provide the structural insights into interactions between FOXO4 and p53 but also highlight their potential as targets for developing senolytic compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
16
Issue of the periodical within the volume
27 May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
4907
UT code for WoS article
001497890700031
EID of the result in the Scopus database
2-s2.0-105006828567