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Establishment of systemic anti-tumor resistance in mice treated with HPMA-based doxorubicin conjugate containing human intravenous immunoglobulin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F04%3A00107940" target="_blank" >RIV/61388971:_____/04:00107940 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Establishment of systemic anti-tumor resistance in mice treated with HPMA-based doxorubicin conjugate containing human intravenous immunoglobulin

  • Original language description

    N-(2-hydroxypropyl)methacrylamide bearing doxorubicin targeted by polyclonal human immunoglobulin (Intraglobin) is able to cure up to 50% of mice with EL-4 T-cell lymphoma in thearapeutic treatment. In the treated mice specific resistance to the second administration of the same tumor was observed at least 3 months after the treatment and after re-transplantation with the same cancer cells, mice survive without any additional treatment

  • Czech name

    Navození systémové protinádorové rezistence u myší léčených doxorubicinem navázaným na HPMA, který současně nese lidský IV IgG

  • Czech description

    Polymerní konjugát doxorubicinu s N-(2-hydroxypropyl)metakrylamidem směrovaný polyklonálním lidským Ig (Intraglobin) je schopen vyléčit až 50% myší s EL-4 T-buněčným lymfomem v terapeutickém režimu. Navíc se u těcho myší vyvine specifická systémová rezistence proti tomuto nádoru trvající alespoň 3 měsíce a po retransplantaci jsou tyto myši schopny odhojit nádor bez jakékoliv léčby.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Annual Meeting and Exposition of the Controlled Release Society /31./

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    713-714

  • Publisher name

    Neuveden

  • Place of publication

    Honolulu

  • Event location

    Honolulu

  • Event date

    Jun 12, 2004

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article