The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F05%3A00022207" target="_blank" >RIV/61388971:_____/05:00022207 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC
Original language description
At conditions of low iron availability, Neisseria meningitidis produces a family of FrpC-like, type I-secreted RTX proteins of unknown role in meningococcal lifestyle. It is shown here that iron starvation also induces production of FrpD, the other protein expressed from a gene located immediately upstream of the frpC gene in a predicted iron-regulated frpDC operon. We found that FrpD is highly conserved in a set of meningococcal strains representative of all serogroups and does not exhibit any similarity to known sequences of other organisms. Subcellular localization and [3H]palmitic acid labeling in Escherichia coli revealed that FrpD is synthesized with a type II signal peptide for export across the cytoplasmic membrane and is, upon processing to alipoprotein, sorted to the outer bacterial membrane.
Czech name
Lipoprotein FrpD z vnější membrány Neisseria meningitidis váže RTXC protein FrpD
Czech description
V podmínkách limitace růstu meningokoků koncentrací volného železa exprimují tyto protein FrpD. V práci je ukázáno, že se jedná o lipoprotein, který je lokalizovánm do vnější bakteriální membrány a váže sekretovaný RTX protein FrpC z vysokou afinitou
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA310%2F02%2F1448" target="_blank" >GA310/02/1448: Biological activity of the Neisseria meningitidis RTX protein and its role in meningococcal disease</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
280
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
3251-3258
UT code for WoS article
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EID of the result in the Scopus database
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