Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00039366" target="_blank" >RIV/61388971:_____/06:00039366 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing
Original language description
Rationale: The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. Objectives: First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the circumstances of a contact investigation prompted by an unusually severe index case of infectious pulmonary tuberculosis. Second, to investigate the ability of the strain of M. tuberculosis responsible to induce cytokine secretion from monocytes in vitro. Methods: A routine TST-based tuberculosis-contact screening procedure supplemented by the use of an "in house" IFNGRA that assays the T-cell response to the M. tuberculosis-specific antigens ESAT-6, CFP-10 (presented as a fusion protein within the inactivated adenylate cyclase of Bordetella pertussis), and purified protein derivative of M. tuberculosis
Czech name
Přenos Mycobacterium tuberculosis nedetekovaný kožním tuberkulinovým testem
Czech description
Práce ukazuje, že tuberkulinový kožní test, tak jak byl používán v UK (Heaf test) není spolehlivý a nedetekuje infekce atypickými kmeny Mycobacterium tuberculosis. V této práci popisujeme použití nově vyvinutého testu založeného na použití detekce in vitro uvolněného IFNg
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA5020406" target="_blank" >IAA5020406: Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Respiratory and Critical Care Medicine
ISSN
1073-449X
e-ISSN
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Volume of the periodical
173
Issue of the periodical within the volume
-
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1038-1042
UT code for WoS article
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EID of the result in the Scopus database
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