Association of Eukaryotic Translation Initiation Factor 3 (eIF3) with the 40S Ribosome Post the Terminations Step on Short uORF is a Critical Determinant of its Ability to Reinitiate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00097546" target="_blank" >RIV/61388971:_____/07:00097546 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Association of Eukaryotic Translation Initiation Factor 3 (eIF3) with the 40S Ribosome Post the Terminations Step on Short uORF is a Critical Determinant of its Ability to Reinitiate
Original language description
Yeast Initiation factor 3 (eIF3) occurs together with the eIF2.GTP.Met-tRNAiMet ternary complex (TC) and eIFs 1 and 5 in a pre-formed unit called the multifactor complex (MFC) that was implicated in playing a critical role in efficient recruitment of TCand mRNA to the 40S ribosomes and stimulation of the post-assembly processes such as scanning and AUG recognition. In a previous study we demonstrated that deletion of the N-terminal domain (NTD) of the TIF32 subunit of eIF3, in the presence of a wild-type gene, completely eliminated association of the mutant MFC with the 40S ribosome without affecting its overall integrity. In addition, we showed that the TIF32-NTD contains a binding site for the C-terminal domain (CTD) of the small ribosomal protein 0A (RPS0A) that is located on the solvent side of the 40S subunit where the main body of eIF3 was proposed to reside
Czech name
V samotném srdci reiniciace ? eIF3 jako neočekávaný klíčový hráč
Czech description
Práce pojednáva o studiu inciace translace a specifické úloze translačního iniciačního faktoru eIF3
Classification
Type
D - Article in proceedings
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Annual Conference on Yeasts /35./. Programme. Abstracts
ISBN
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ISSN
1336-4839
e-ISSN
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Number of pages
1
Pages from-to
23-23
Publisher name
SAS
Place of publication
Bratislava
Event location
Smolenice
Event date
May 16, 2007
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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