Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00328368" target="_blank" >RIV/61388971:_____/09:00328368 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/09:00008266
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells
Original language description
The proteins of 14-3-3 family are substantially involved in the regulation of many biological processes including the apoptosis. We studied the changes in the expression of five 14-3-3 isoforms during the apoptosis of JURL-MK1 and K562 cells. The expression level of all these proteins markedly decreased in relation with the apoptosis progression and all isoforms underwent truncation, which probably corresponds to the removal of several C-terminal amino acids. The observed 14-3-3 modifications were partially blocked by caspase-3 inhibition
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/NR9243" target="_blank" >NR9243: Study of the disturbancies of cell adhesion regulation in hematological malignancies</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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