Genetic Control of Biosynthesis of Secondary Metabolites ? Lincosamide Antibiotics as Examples
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00340932" target="_blank" >RIV/61388971:_____/09:00340932 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genetic Control of Biosynthesis of Secondary Metabolites ? Lincosamide Antibiotics as Examples
Original language description
Lincomycin and its derivatives are potent antibiotics used in human and veterinary medicine. Lincomycin molecule is composed of two subunits, methylthiolincosamide (MTL) and methylproline linked by an amide bond. The gene cluster of Streptomyces lincolnensis controlling lincomycin biosynthesis contains 29 ORFs with putative biosynthetic/regulatory (lmb) and resistance (lmr) functions. Six ORFs (lmbA, B1, B2, W, X, Y) were found to have their counterparts among genes controlling biosynthesis of anthramycin sharing with lincomycin the initial reactions of biosynthesis of proline derivatives. Functions of LmbB1 and LmbB2 proteins were demonstrated in vitro; by gene inactivation analysis lmbA, X, W genes were confirmed to be included in propylproline biosynthesis
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA500200810" target="_blank" >IAA500200810: Genes determining critical steps in designing the producers of hybrid lincosamide antibiotics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů