Cytokine expression and signaling in drug-induced cellular senescence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00333900" target="_blank" >RIV/61388971:_____/10:00333900 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/10:00333900

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Cytokine expression and signaling in drug-induced cellular senescence

Original language description

Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Pathophysiologically relevant part of senescent phenotype is the expression and secretion of several cytokines. In this article we present that premature cellular senescence promoted by senescence-inducing compounds (e.g. bromodeoxyuridine, distamycin A, hydroxyurea, and aphidicoline) in several human tumor cell lines is accompanied by persistent activity of the interferon JAK/STAT signaling pathway and the expression of several interferon-stimulated genes such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7. JAK1/STAT-activating ligands IL-10, IL-20, IL-24, IFNgamma, IFNbeta and IL-6were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT. Furthermore, cytokine genes including proinflammatory IL-1, TNF and TGF families were highly expressed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000273650000010

EID of the result in the Scopus database

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