Gliadin fragments promote migration of dendritic cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F11%3A00361617" target="_blank" >RIV/61388971:_____/11:00361617 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1582-4934.2010.01066.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2010.01066.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1582-4934.2010.01066.x" target="_blank" >10.1111/j.1582-4934.2010.01066.x</a>
Alternative languages
Result language
angličtina
Original language name
Gliadin fragments promote migration of dendritic cells
Original language description
This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsivenessto the lymph node-homing chemokines CCL19 and CCL21
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
938-948
UT code for WoS article
000290312700019
EID of the result in the Scopus database
—