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Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-? and interleukin-18 in BALB/c and severe combined immunodeficiency mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00377981" target="_blank" >RIV/61388971:_____/12:00377981 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985823:_____/12:00377981

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1365-2249.2011.04498.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-2249.2011.04498.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1365-2249.2011.04498.x" target="_blank" >10.1111/j.1365-2249.2011.04498.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-? and interleukin-18 in BALB/c and severe combined immunodeficiency mice

  • Original language description

    One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bakterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 weekprior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms ? bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Immunology

  • ISSN

    0009-9104

  • e-ISSN

  • Volume of the periodical

    167

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    356-365

  • UT code for WoS article

    000299037700021

  • EID of the result in the Scopus database