Patterns of Early Gut Colonization Shape Future Immune Responses of the Host

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00378860" target="_blank" >RIV/61388971:_____/12:00378860 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0034043" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0034043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0034043" target="_blank" >10.1371/journal.pone.0034043</a>

Result language
angličtina
Original language name
Patterns of Early Gut Colonization Shape Future Immune Responses of the Host
Original language description
The most important trigger for immune system development is the exposure to microbial components immediately after birth. Moreover, targeted manipulation of the microbiota can be used to change host susceptibility to immune-mediated diseases. Our aim wasto analyze how differences in early gut colonization patterns change the composition of the resident microbiota and future immune system reactivity. Germ-free (GF) mice were either inoculated by single oral gavage of caecal content or let colonized by co-housing with specific pathogen-free (SPF) mice at different time points in the postnatal period. The microbiota composition was analyzed by denaturing gradient gel electrophoresis for 16S rRNA gene followed by principal component analysis
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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