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Polymer carriers for anticancer drugs targeted to EGF receptor

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00384522" target="_blank" >RIV/61388971:_____/12:00384522 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/12:00384522

  • Result on the web

    <a href="http://dx.doi.org/10.1002/mabi.201200270" target="_blank" >http://dx.doi.org/10.1002/mabi.201200270</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/mabi.201200270" target="_blank" >10.1002/mabi.201200270</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polymer carriers for anticancer drugs targeted to EGF receptor

  • Original language description

    A novel actively targeted polymer carrier for anticancer drugs based on an N-(2-hydroxypropyl)methacrylamide copolymer (PHPMA) is proposed. An oligopeptide sequence GE7, attached to the polymer, is a specific ligand for the EGF receptor overexpressed onmost tumor cells. Co-attachment of selected chemotherapeutics will therefore lead to formation of tumorspecific polymer therapeutics, further enhanced by the EPR effect. FACS measurements prove elevated binding activity of the fluorescently labeled PHPMA/GE7 conjugate in EGFR-rich cells (FaDu, MCF-7), compared to conjugates of scrambled peptides. Cell lines with low EGFR level (SW620, B16F10) bind the GE7 conjugate significantly less.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/IAAX00500803" target="_blank" >IAAX00500803: Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Macromolecular Bioscience

  • ISSN

    1616-5187

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    1714-1720

  • UT code for WoS article

    000312242600014

  • EID of the result in the Scopus database