Polymer carriers for anticancer drugs targeted to EGF receptor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00384522" target="_blank" >RIV/61388971:_____/12:00384522 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/12:00384522
Result on the web
<a href="http://dx.doi.org/10.1002/mabi.201200270" target="_blank" >http://dx.doi.org/10.1002/mabi.201200270</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201200270" target="_blank" >10.1002/mabi.201200270</a>
Alternative languages
Result language
angličtina
Original language name
Polymer carriers for anticancer drugs targeted to EGF receptor
Original language description
A novel actively targeted polymer carrier for anticancer drugs based on an N-(2-hydroxypropyl)methacrylamide copolymer (PHPMA) is proposed. An oligopeptide sequence GE7, attached to the polymer, is a specific ligand for the EGF receptor overexpressed onmost tumor cells. Co-attachment of selected chemotherapeutics will therefore lead to formation of tumorspecific polymer therapeutics, further enhanced by the EPR effect. FACS measurements prove elevated binding activity of the fluorescently labeled PHPMA/GE7 conjugate in EGFR-rich cells (FaDu, MCF-7), compared to conjugates of scrambled peptides. Cell lines with low EGFR level (SW620, B16F10) bind the GE7 conjugate significantly less.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAAX00500803" target="_blank" >IAAX00500803: Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
12
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1714-1720
UT code for WoS article
000312242600014
EID of the result in the Scopus database
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