Hormonal activities of new brominated flame retardants

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00390233" target="_blank" >RIV/61388971:_____/12:00390233 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.chemosphere.2011.12.049" target="_blank" >http://dx.doi.org/10.1016/j.chemosphere.2011.12.049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chemosphere.2011.12.049" target="_blank" >10.1016/j.chemosphere.2011.12.049</a>

Result language
angličtina
Original language name
Hormonal activities of new brominated flame retardants
Original language description
After the phase-out of two commercial mixtures of brominated flame retardants, an increasing number of alternative flame retardants have been introduced in commercial applications. None of them, however, has been thoroughly tested for its hormonal activity. We used two yeast reporter-gene assays to determine the potential of eleven compounds to interfere with estrogenic and androgenic pathways. Our data demonstrate the ability of 2,4,6-tribromophenol to lower the transcriptional activity of human estrogen and androgen receptors. A nominal IC50 value of 14.1 mu M for anti-estrogenic and 3.9 mu M for anti-androgenic activity was obtained using the luciferase reporter. An IC50 value of 9.2 mu M was calculated for the anti-estrogenic activity measured by the beta-galactosidase assay. Of the tested chemicals, this study highlights the endocrine disrupting effects of 2,4,6-tribromophenol whose occurrence in the environment should be monitored
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/GA104%2F09%2F0694" target="_blank" >GA104/09/0694: Advanced Photocatalytic Processes - Nanotechnology for Environmental</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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