Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00421314" target="_blank" >RIV/61388971:_____/13:00421314 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/13:00421314 RIV/67985904:_____/13:00421314
Result on the web
<a href="http://dx.doi.org/10.1097/MIB.0b013e318281330a" target="_blank" >http://dx.doi.org/10.1097/MIB.0b013e318281330a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MIB.0b013e318281330a" target="_blank" >10.1097/MIB.0b013e318281330a</a>
Alternative languages
Result language
angličtina
Original language name
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice
Original language description
Microbial sensing by Toll-like receptors (TLR) and its negative regulation have an important role in the pathogenesis of inflammation-related cancer. In this study, we investigated the role of negative regulation of Toll-like receptors signaling and gutmicrobiota in the development of colitis-associated cancer in mouse model. We conclude that gut microbiota promotes tumorigenesis by increasing the exposure of gut epithelium to carcinogens and that IRAK-M-negative regulation is essential for colon cancer resistance even in conditions of altered microbiota. Therefore, gut microbiota and its metabolic activity could be potential targets for colitis-associated cancer therapy
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inflammatory Bowel Diseases
ISSN
1078-0998
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1266-1277
UT code for WoS article
000329353200025
EID of the result in the Scopus database
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