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HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00421776" target="_blank" >RIV/61388971:_____/13:00421776 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/13:00421776

  • Result on the web

    <a href="http://dx.doi.org/10.1002/mabi.201300288" target="_blank" >http://dx.doi.org/10.1002/mabi.201300288</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/mabi.201300288" target="_blank" >10.1002/mabi.201300288</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy

  • Original language description

    The synthesis, characterization, and results of evaluation of the biological behavior of N-(2-hydroxy-propyl)methacrylamide (HPMA) copolymer conjugates bearing anti-cancer drugs doxorubicin and mitomycin C are described. Two HPMA copolymer carrier typeswere synthesized: the linear copolymer and the biodegradable high-molecular-weight diblock copolymer containing a degradable disulfide bond. The polymer-drug conjugates incubated in buffers modeling the intracellular environment released the drugs more rapidly than those incubated in bloodstream conditions. Significant in vitro and in vivo antitumor synergistic activity of the conjugates in the treatment of EL-4 T-cell demonstrates their high potential for solid tumor treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Macromolecular Bioscience

  • ISSN

    1616-5187

  • e-ISSN

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    13

  • Pages from-to

    1648-1660

  • UT code for WoS article

    000329994400003

  • EID of the result in the Scopus database