HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00421776" target="_blank" >RIV/61388971:_____/13:00421776 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/13:00421776
Result on the web
<a href="http://dx.doi.org/10.1002/mabi.201300288" target="_blank" >http://dx.doi.org/10.1002/mabi.201300288</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201300288" target="_blank" >10.1002/mabi.201300288</a>
Alternative languages
Result language
angličtina
Original language name
HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy
Original language description
The synthesis, characterization, and results of evaluation of the biological behavior of N-(2-hydroxy-propyl)methacrylamide (HPMA) copolymer conjugates bearing anti-cancer drugs doxorubicin and mitomycin C are described. Two HPMA copolymer carrier typeswere synthesized: the linear copolymer and the biodegradable high-molecular-weight diblock copolymer containing a degradable disulfide bond. The polymer-drug conjugates incubated in buffers modeling the intracellular environment released the drugs more rapidly than those incubated in bloodstream conditions. Significant in vitro and in vivo antitumor synergistic activity of the conjugates in the treatment of EL-4 T-cell demonstrates their high potential for solid tumor treatment.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
12
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
1648-1660
UT code for WoS article
000329994400003
EID of the result in the Scopus database
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