ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00422123" target="_blank" >RIV/61388971:_____/13:00422123 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellsig.2013.08.024" target="_blank" >http://dx.doi.org/10.1016/j.cellsig.2013.08.024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellsig.2013.08.024" target="_blank" >10.1016/j.cellsig.2013.08.024</a>

Result language
angličtina
Original language name
ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype
Original language description
The ERR (extracellular signal-regulated kinases) cascade has an evolutionarily conserved three tier architecture consisting of protein kinases Raf, MEK (MAPK/ERK kinase) and ERK Following activation, ERK phosphorylates various cellular elements leading to diverse cellular responses. Downstream of ERK the family of p90 ribosomal 56 kinases (RSKs) has been proven to be an important conveyor of ERK signaling, however, little is known if ERK and RSK coordinate their functions to generate a specific biological response. Here we show that in epithelial cells conditional activation of the ERK pathway causes phenotypic conversion of epithelial cells to autonomously migrating cells, This process involves two sequential steps characterized by loss of apical-basal polarity followed by cell scattering. The activation of ERR, but not RSK, is sufficient for the execution of the first step and it requires calpain mediated remodeling of actin cytoskeleton. Conversely, RSK regulates the successive stag
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)