Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00422897" target="_blank" >RIV/61388971:_____/13:00422897 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/mi.2012.92" target="_blank" >http://dx.doi.org/10.1038/mi.2012.92</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/mi.2012.92" target="_blank" >10.1038/mi.2012.92</a>
Alternative languages
Result language
angličtina
Original language name
Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells
Original language description
As the Bacillus Calmette-Guerin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein family (ESX) antigens for the evaluation of a novel vaccine delivery strategy that enables versatile in vivo targeting of antigens into specialized dendritic cell (DC) subsets. ESX antigenswere genetically fused to the tetramerizing core of streptavidin (SA) to form high-affinity complexes with biotin (biot)-conjugated antibodies recognizing DC surface receptors. When directed through the CD11b or CD11c beta(2)-integrins or diverse C-typelectins, the ESX-SA:biot-antibody complexes were efficiently captured and presented on major histocompatibility complex molecules of DCs to specific T-cell receptors. Robust ESX-specific T-cell responses were induced by immunization with
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/KAN200520702" target="_blank" >KAN200520702: Nanoimmunosensors for detection of cytokines</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mucosal Immunology
ISSN
1933-0219
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
522-534
UT code for WoS article
000317722800009
EID of the result in the Scopus database
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