Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00424855" target="_blank" >RIV/61388971:_____/13:00424855 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/es403470s" target="_blank" >http://dx.doi.org/10.1021/es403470s</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/es403470s" target="_blank" >10.1021/es403470s</a>

Result language

angličtina

Original language name

Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

Original language description

Flumequine, a fluoroquinolone antibiotic, is applied preferably in veterinary medicine, for stock breeding and treatment of aquacultures. Formation of drug resistance is a matter of general concern when antibiotics such as flumquine occur in the environment. Thus, biodegradation of flumequine in solution was investigated using five different ligninolytic fungi. Irpex lacteus, Dichomitus squalens, and Trametes versicolor proved most efficient and transformed more than 90% of flumequine within 6 or even 3days. Pan us tigrinus and Pleurotus ostreatus required up to 14 days to remove >90% of flumequine. Analyses of the metabolites by liquid chromatography mass spectrometry suggest different transformation pathways for the different fungal strains. Structure proposals were elaborated for 8 metabolites. 7-Hydroxy-flumequine and flumequine ethyl ester were identified as common metabolites produced by all ligninolytic fungi. The largest variety of metabolites was formed by D. squalens. Residu

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/TE01020218" target="_blank" >TE01020218: Environmental friendly nanotechnologies and biotechnologies in water and soil treatment</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Science and Technology

ISSN

0013-936X

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

24

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

14128-14136

UT code for WoS article

000328796900028

EID of the result in the Scopus database

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