The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425609" target="_blank" >RIV/61388971:_____/13:00425609 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1042/BJ20120312" target="_blank" >http://dx.doi.org/10.1042/BJ20120312</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/BJ20120312" target="_blank" >10.1042/BJ20120312</a>

Result language
angličtina
Original language name
The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies
Original language description
On solid substrates, yeast colonies pass through distinct developmental phases characterized by the changes in pH of their surroundings from acidic to nearly alkaline and vice versa. At the beginning of the alkali phase colonies start to produce ammonia,which functions as a quorum-sensing molecule inducing the reprogramming of cell metabolism. Such reprogramming includes, among others, the activation of several plasma membrane transporters and is connected with colony differentiation. In the present study, we show that colony cells can use two transport mechanisms to import lactic acid: a 'saturable' component of the transport, which requires the presence of a functional Jen1p transporter, and a 'non-saturable' component (diffusion) that is independent of Jen1p. During colony development, the efficiency of both transport components changes similarly in central and outer colonial cells. Although the lactate uptake capacity of central cells gradually decreases during colony development,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GA204%2F08%2F0718" target="_blank" >GA204/08/0718: Role of ammonia signalling in yeast colony differentiation, development, ageing and survival: Molecular mechanisms and functions.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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