The Reorientation of Cell Nucleus Promotes the Establishment of Front-Rear Polarity in Migrating Fibroblasts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425616" target="_blank" >RIV/61388971:_____/13:00425616 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jmb.2013.02.034" target="_blank" >http://dx.doi.org/10.1016/j.jmb.2013.02.034</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmb.2013.02.034" target="_blank" >10.1016/j.jmb.2013.02.034</a>

Result language
angličtina
Original language name
The Reorientation of Cell Nucleus Promotes the Establishment of Front-Rear Polarity in Migrating Fibroblasts
Original language description
The establishment of cell polarity is an essential step in the process of cell migration. This process requires precise spatiotemporal coordination of signaling pathways that in most cells create the typical asymmetrical profile of a polarized cell withnucleus located at the cell rear and the microtubule organizing center (MTOC) positioned between the nucleus and the leading edge. During cell polarization, nucleus rearward positioning promotes correct microtubule organizing center localization and thusthe establishment of front rear polarity and directional migration. We found that cell polarization and directional migration require also the reorientation of the nucleus. Nuclear reorientation is manifested as temporally restricted nuclear rotation that aligns the nuclear axis with the axis of cell migration. We also found that nuclear reorientation requires physical connection between the nucleus and cytoskeleton mediated by the LINC (linker of nucleoskeleton and cytoskeleton) comple
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GA204%2F09%2F0614" target="_blank" >GA204/09/0614: The regulatory function of the ERK pathway in the spatial distribution of intracellular organelles.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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