Two optimized synthetic pathways toward a chiral precursor of Mivacurium chloride and other skeletal muscle relaxants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425876" target="_blank" >RIV/61388971:_____/13:00425876 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/13:43894378
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetasy.2012.11.012" target="_blank" >http://dx.doi.org/10.1016/j.tetasy.2012.11.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetasy.2012.11.012" target="_blank" >10.1016/j.tetasy.2012.11.012</a>
Alternative languages
Result language
angličtina
Original language name
Two optimized synthetic pathways toward a chiral precursor of Mivacurium chloride and other skeletal muscle relaxants
Original language description
A chiral precursor of Mivacurium chloride, (R)-5'-methoxylaudanosine, was prepared using two different methods. The chiral resolution of racemic 5'-methoxylaudanosine, typically used in industry, was carried out in parallel with a procedure consisting ofasymmetric transfer hydrogenation (ATH) and reductive methylation. A novel one-pot synthetic step was developed for the synthesis of racemic 5'-methoxylaudanosine. In both routes, the enantioselectivity was high but further purification was necessary toreach the level of a pharmaceutical standard. The individual synthetic steps reported herein can also be used for the synthesis of analogous bistetrahydroisoquinoline-based skeletal muscle relaxants.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tetrahedron Asymmetry
ISSN
0957-4166
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
50-55
UT code for WoS article
000314488700007
EID of the result in the Scopus database
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