The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00435549" target="_blank" >RIV/61388971:_____/14:00435549 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/s13567-014-0091-x" target="_blank" >http://dx.doi.org/10.1186/s13567-014-0091-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13567-014-0091-x" target="_blank" >10.1186/s13567-014-0091-x</a>

Result language
angličtina
Original language name
The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2
Original language description
Lymphocyte subsets isolated from germ-free piglets experimentally infected with swine influenza virus (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) or porcine circovirus type 2 (PCV2) were studied and the profile of these subsets among these three infections was monitored. Germ-free piglets were used since their response could be directly correlated to the viral infection. Because SIV infections are resolved even by colostrum-deprived neonates whereas PRRSV and PCV2 infections are not, SIV was used as a benchmark for an effectively resolved viral infection. PRRSV caused a large increase in the proportion of lymphocytes at the site of infection and rapid differentiation of B cells leading to a high level of Ig-producing cells but asevere reduction in CD2(-)CD21(+) primed B cells. Unlike SIV and PCV2, PRRSV also caused an increase in terminally differentiated subset of CD2(+)CD8 alpha(+) gamma delta cells and polyclonal expansion of major V beta families suggesting
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: The role of gammadelta T cells in immunization of porcine naive immune system</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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