Degradation of biologically active substances by vapor-phase hydrogen peroxide

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00506883" target="_blank" >RIV/61388971:_____/14:00506883 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11164-012-0987-x" target="_blank" >https://link.springer.com/article/10.1007%2Fs11164-012-0987-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11164-012-0987-x" target="_blank" >10.1007/s11164-012-0987-x</a>

Result language
angličtina
Original language name
Degradation of biologically active substances by vapor-phase hydrogen peroxide
Original language description
We have examined the potential of vapor-phase hydrogen peroxide (VPHP) for degradation of 21 structurally different pharmaceutical substances. Our results show that VPHP can be used to degrade pharmaceuticals, but it was not universally applicable to all the drugs tested. Structural analysis revealed a significant correlation of the molecular structure of a compound with its susceptibility to VPHP. Tertiary amino groups seem to be the initiation centers, although the overall susceptibility of a substance depends on other factors also. Several tested substances underwent significant structural changes, suggesting a possible decrease in their biological activity. As far as we are aware, this is one of the first reports of application of VPHP to the decontamination of hazardous chemicals.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)