Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00456423" target="_blank" >RIV/61388971:_____/15:00456423 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/15:00456423 RIV/00216208:11310/15:10324443

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.10766" target="_blank" >http://dx.doi.org/10.7554/eLife.10766</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.10766" target="_blank" >10.7554/eLife.10766</a>

Result language

angličtina

Original language name

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

Original language description

Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site. The ligands preferentially engage the active forms of the integrins and trigger signaling cascades that alter numerous cell functions. Here we found that the adenylate cyclase toxin (CyaA), a key virulence factor of the whooping cough agent Bordetella pertussis, preferentially binds an inactive form of the integrin complement receptor 3 (CR3), using a site outside of its I-domain. CyaA binding did not trigger downstream signaling of CR3 in human monocytes and CyaAcatalyzed elevation of cAMP effectively blocked CR3 signaling initiated by a natural ligand. This unprecedented type of integrin-ligand interaction distinguishes CyaA from all other known ligands of the I-domain-containing integrins and provides a mechanistic insight into the previously observed central role of CyaA in the pathogenesis of B.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

DEC 9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

28

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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