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Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462004" target="_blank" >RIV/61388971:_____/16:00462004 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3390/ijms17060899" target="_blank" >http://dx.doi.org/10.3390/ijms17060899</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ijms17060899" target="_blank" >10.3390/ijms17060899</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties

  • Original language description

    A series of isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) esters with mono-or dicarboxylic acids was designed to modulate hydro-and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C-5- to C-12-dicarboxylic acids; the shorter ones, such as oxalic (C-2), malonic (C-3), succinic (C-4) and maleic (C-4) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin-Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1422-0067

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    000378799300113

  • EID of the result in the Scopus database

    2-s2.0-84973320224