Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462004" target="_blank" >RIV/61388971:_____/16:00462004 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/ijms17060899" target="_blank" >http://dx.doi.org/10.3390/ijms17060899</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms17060899" target="_blank" >10.3390/ijms17060899</a>
Alternative languages
Result language
angličtina
Original language name
Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties
Original language description
A series of isoquercitrin (quercetin-3-O-beta-D-glucopyranoside) esters with mono-or dicarboxylic acids was designed to modulate hydro-and lipophilicity and biological properties. Esterification of isoquercitrin was accomplished by direct chemoenzymatic reaction using Novozym 435 (lipase from Candida antarctica), which accepted C-5- to C-12-dicarboxylic acids; the shorter ones, such as oxalic (C-2), malonic (C-3), succinic (C-4) and maleic (C-4) acids were not substrates of the lipase. Lipophilicity of monocarboxylic acid derivatives, measured as log P, increased with the chain length. Esters with glutaric and adipic acids exhibited hydrophilicity, and the dodecanedioic acid hemiester was more lipophilic. All derivatives were less able to reduce Folin-Ciocalteau reagent (FCR) and scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) than isoquercitrin; ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) radical-scavenging activity was comparable.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
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UT code for WoS article
000378799300113
EID of the result in the Scopus database
2-s2.0-84973320224