Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462031" target="_blank" >RIV/61388971:_____/16:00462031 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3762/bjoc.12.66" target="_blank" >http://dx.doi.org/10.3762/bjoc.12.66</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjoc.12.66" target="_blank" >10.3762/bjoc.12.66</a>

Result language
angličtina
Original language name
Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins
Original language description
Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. This represents the only one-pot semi-synthetic method to access these flavonolignans in high yields.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/LD15085" target="_blank" >LD15085: Enzymatic preparation of biologically active glycoside-based metabolites</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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