Acquisition of exogenous haem is essential for tick reproduction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00463424" target="_blank" >RIV/61388971:_____/16:00463424 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/16:00463424 RIV/60076658:12310/16:43891009

Result on the web

<a href="http://dx.doi.org/10.7554/eLife.12318" target="_blank" >http://dx.doi.org/10.7554/eLife.12318</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.12318" target="_blank" >10.7554/eLife.12318</a>

Result language

angličtina

Original language name

Acquisition of exogenous haem is essential for tick reproduction

Original language description

Haem and iron homeostasis in most eukaryotic cells is based on a balanced flux between haem biosynthesis and haem oxygenase-mediated degradation. Unlike most eukaryotes, ticks possess an incomplete haem biosynthetic pathway and, together with other (non-haematophagous) mites, lack a gene encoding haem oxygenase. We demonstrated, by membrane feeding, that ticks do not acquire bioavailable iron from haemoglobin-derived haem. However, ticks require dietary haemoglobin as an exogenous source of haem since, feeding with haemoglobin-depleted serum led to aborted embryogenesis. Supplementation of serum with haemoglobin fully restored egg fertility. Surprisingly, haemoglobin could be completely substituted by serum proteins for the provision of amino-acids in vitellogenesis. Acquired haem is distributed by haemolymph carrier protein(s) and sequestered by vitellins in the developing oocytes. This work extends, substantially, current knowledge of haem auxotrophy in ticks and underscores the importance of haem and iron metabolism as rational targets for anti-tick interventions.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

Mar 7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

21

Pages from-to

—

UT code for WoS article

000373891500001

EID of the result in the Scopus database

2-s2.0-84964301646