Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00467813" target="_blank" >RIV/61388971:_____/16:00467813 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.dci.2016.07.020" target="_blank" >http://dx.doi.org/10.1016/j.dci.2016.07.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2016.07.020" target="_blank" >10.1016/j.dci.2016.07.020</a>

Result language
angličtina
Original language name
Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets
Original language description
The Heal Peyers patches (IPP) of newborn germfree (GF) piglets were isolated into blind loops and the piglets colonized with a defined probiotic microflora. After 5 weeks, IgA levels in the intestinal lavage (IL) of loop piglets remained at GF levels and IgM comprised similar to 70% while in controls, IgA levels were elevated 5-fold and comprised similar to 70% of total Igs. Loop piglets also had. reduced serum IgA levels suggesting the source of serum IgA had been interrupted. The isotype profile for loop contents was intermediate between that in the IL of GF and probiotic controls. Surprisingly, colonization alone did not result in repertoire diversification in the IPP. Rather, colonization promoted pronounced proliferation of fully switched IgA(+)IgM(-) B cells in the IPP that supply early, non-diversified "natural" SIgA antibodies to the gut lumen and a primary IgA response in serum.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/GA15-02274S" target="_blank" >GA15-02274S: The role of immunoglobulin light chains in the development of porcine B cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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