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IgA nephropathy enigma

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00469665" target="_blank" >RIV/61388971:_____/16:00469665 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/16:10329291 RIV/61989592:15110/16:33162259

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.clim.2016.07.011" target="_blank" >http://dx.doi.org/10.1016/j.clim.2016.07.011</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.clim.2016.07.011" target="_blank" >10.1016/j.clim.2016.07.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    IgA nephropathy enigma

  • Original language description

    IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis in the world. The disease is characterized by the presence of IgA-containing immune complexes in the circulation and in mesangial deposits with ensuing glomerular injury. Although in humans there are two IgA subclasses, only IgA1 molecules are involved. The exclusivity of participation of IgA1 in IgAN prompted extensive structural and immunological studies of the unique hinge region (HR) of IgA1, which is absent in otherwise highly homologous IgA2. HR of IgA1 with altered O-glycans serves as an antigen recognized by autoantibodies specific for aberrant HR glycans leading to the generation of nephritogenic immune complexes. However, there are several unresolved questions concerning the phylogenetic origin of human IgA1 HR, the structural basis of its antigenicity, the origin of antibodies specific for HR with altered glycan moieties, the regulatory defects in IgAl glycosylation pathways, and the potential approaches applicable to the disease-specific interventions in the formation of nephritogenic immune complexes. This review focuses on the gaps in our knowledge of molecular and cellular events that are involved in the immunopathogenesis of IgAN.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical Immunology

  • ISSN

    1521-6616

  • e-ISSN

  • Volume of the periodical

    172

  • Issue of the periodical within the volume

    NOV 2016 SI

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    72-77

  • UT code for WoS article

    000388056200012

  • EID of the result in the Scopus database

    2-s2.0-84993999910