IgA nephropathy enigma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00469665" target="_blank" >RIV/61388971:_____/16:00469665 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10329291 RIV/61989592:15110/16:33162259
Result on the web
<a href="http://dx.doi.org/10.1016/j.clim.2016.07.011" target="_blank" >http://dx.doi.org/10.1016/j.clim.2016.07.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clim.2016.07.011" target="_blank" >10.1016/j.clim.2016.07.011</a>
Alternative languages
Result language
angličtina
Original language name
IgA nephropathy enigma
Original language description
IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis in the world. The disease is characterized by the presence of IgA-containing immune complexes in the circulation and in mesangial deposits with ensuing glomerular injury. Although in humans there are two IgA subclasses, only IgA1 molecules are involved. The exclusivity of participation of IgA1 in IgAN prompted extensive structural and immunological studies of the unique hinge region (HR) of IgA1, which is absent in otherwise highly homologous IgA2. HR of IgA1 with altered O-glycans serves as an antigen recognized by autoantibodies specific for aberrant HR glycans leading to the generation of nephritogenic immune complexes. However, there are several unresolved questions concerning the phylogenetic origin of human IgA1 HR, the structural basis of its antigenicity, the origin of antibodies specific for HR with altered glycan moieties, the regulatory defects in IgAl glycosylation pathways, and the potential approaches applicable to the disease-specific interventions in the formation of nephritogenic immune complexes. This review focuses on the gaps in our knowledge of molecular and cellular events that are involved in the immunopathogenesis of IgAN.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Immunology
ISSN
1521-6616
e-ISSN
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Volume of the periodical
172
Issue of the periodical within the volume
NOV 2016 SI
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
72-77
UT code for WoS article
000388056200012
EID of the result in the Scopus database
2-s2.0-84993999910